[6] EMA, “Guideline on Quality, non-clinical and clinical aspects of live recombinant
viral vectored vaccines,” Reproduction, vol. 44, no. November, pp. 1–14, 2009.
[7] R. Morenweiser, “Downstream processing of viral vectors and vaccines,” Gene
Ther., vol. 12, pp. S103–S110, 2005.
[8] H. Ugai et al., “Purification of infectious adenovirus in two hours by ultra-
centrifugation and tangential flow filtration,” Biochem. Biophys. Res. Commun., vol.
331, no. 4, pp. 1053–1060, 2005.
[9] S. Zolotukhin et al., “Recombinant adeno-associated virus purification using novel
methods improves infectious titer and yield,” Gene Ther., vol. 6, no. 6, pp. 973–985,
1999.
[10] C. B. Reimer, R. S. Baker, T. E. Newlin, and M. L. Havens, “Influenza virus
purification with the zonal ultracentrifuge,” Science, vol. 152, no. 3727, pp. 1379
LP–1381, Jun. 1966.
[11] J. Hilfenhaus, R. Köhler, and F. Behrens, “Large-scale purification of animal viruses
in the RK-model zonal ultracentrifuge: II. Influenza, mumps and Newcastle disease
viruses,” J. Biol. Stand., vol. 4, no. 4, pp. 273–283, 1976.
[12] M. M. Segura, M. Mangion, B. Gaillet, and A. Garnier, “New developments
in lentiviral vector design, production and purification,” Expert Opin. Biol. Ther.,
vol. 13, no. 7, pp. 987–1011, Aug. 2013.
[13] G. Iyer et al., “Reduced surface area chromatography for flow-through purification of
viruses and virus like particles,” J. Chromatogr. A, vol. 1218, no. 26, pp. 3973–3981,
2011.
[14] R. M. Anderson, P. J. Scannon, and J. T. Matthews, “Planning for pandemics of
infectious diseases 30 Years of commercial experience,” 2006.
[15] A. C. Silva et al., “Adenovirus vector production and purification,” Curr. Gene
Ther., vol. 10, no. 6, pp. 437–455, Dec. 2010.
[16] C. Peixoto, M. F. Q. Sousa, A. C. Silva, M. J. T. Carrondo, and P. M. Alves,
“Downstream processing of triple layered rotavirus like particles,” J. Biotechnol.,
vol. 127, no. 3, pp. 452–461, 2007.
[17] O.-W. Merten, M. Schweizer, P. Chahal, and A. Kamen, “Manufacturing of viral
vectors: part II. Downstream processing and safety aspects,” Pharm. Bioprocess.,
vol. 2, no. 3, pp. 237–251, 2014.
[18] A. Kamen and O. Henry, “Development and optimization of an adenovirus pro-
duction process,” J. Gene Med., vol. 6, no. SUPPL. 1, pp. 184–192, 2004.
[19] N. E. Altaras, J. G. Aunins, R. K. Evans, A. Kamen, J. O. Konz, and J. J. Wolf,
“Production and formulation of adenovirus vectors,” Adv. Biochem. Eng. Biotechnol.,
vol. 99, no. November, pp. 193–260, 2005.
[20] E. J. D’Hondt and H. B. Engelmann, “Process for producting influeza vaccine,”
2010.
[21] F. Colavita et al., “Evaluation of the inactivation effect of Triton X-100 on Ebola
virus infectivity,” J. Clin. Virol., vol. 86, pp. 27–30, 2017.
[22] M. G. Moleirinho et al., “Clinical-grade oncolytic adenovirus purification using
polysorbate 20 as an alternative for cell lysis,” Curr. Gene Ther., vol. 18, no. 6,
pp. 366–374, 2018.
[23] P. Guo, Y. El‐Gohary, K. Prasadan, C. Shiota, X. Xiao, J. Wiersch, J. Paredes, S.
Tulachan, G. K. Gittes, “Rapid and simplified purification of recombinant adeno-
associated virus,” J. Virol. Methods vol. 183, no. 2, pp. 139–146, 2013. doi: 10.1016/
j.jviromet.2012.04.004
[24] S. Zhang, C. Thwin, Z. Wu, T. Cho, and S. Gallagher, “Method for the production
and purification of adenoviral vectors,” 2010.
[25] L. Besnard et al., “Clarification of vaccines: An overview of filter based technology
trends and best practices,” Biotechnol. Adv., vol. 34, no. 1, pp. 1–13, 2016.
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